| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5224RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UCHL5 |
| Gene ID: |
51377 |
| Uniprot ID: |
UCHL5_HUMAN |
| Immunogen Region: |
1-329 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-329 of human UCH37/UCHL5. (NP_057068.1). |
| Immunogen Sequence: |
MTGNAGEWCLMESDPGVFTE LIKGFGCRGAQVEEIWSLEP ENFEKLKPVHGLIFLFKWQP GEEPAGSVVQDSRLDTIFFA KQVINNACATQAIVSVLLNC THQDVHLGETLSEFKEFSQS FDAAMKGLALSNSDVIRQVH NSFARQQMFEFDTKTSAKEE DAFHFVSYVPVNGRLYELDG LREGPIDLGACNQDDWISAV RPVIEKRIQKYSEGEIRFNL MAIVSDRKMIYEQKIAELQ |
| Function | Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex.however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L5Uch-L5Ubiquitin C-Terminal Hydrolase Uch37Ubiquitin Thioesterase L5 |
| Database Links | Reactome: R-HSA-2173788Reactome: R-HSA-5689603 |
| Cellular Localisation | CytoplasmNucleusAssociates With The Proteasome 19s Subunit In The CytoplasmAssociates With The Ino80 Complex In The Nucleus |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L5 antibodyAnti-Uch-L5 antibodyAnti-Ubiquitin C-Terminal Hydrolase Uch37 antibodyAnti-Ubiquitin Thioesterase L5 antibodyAnti-UCHL5 antibodyAnti-UCH37 antibodyAnti-AD-019 antibodyAnti-CGI-70 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
