| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UBLCP1 (99-318) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UBLCP1 |
| Gene ID: |
134510 |
| Uniprot ID: |
UBCP1_HUMAN |
| Immunogen Region: |
99-318 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 99-318 of human UBLCP1 (NP_659486.2). |
| Immunogen Sequence: |
FDIEDEVVEVENREENLLKI SRRVKEYKVEILNPPREGKK LLVLDVDYTLFDHRSCAETG VELMRPYLHEFLTSAYEDYD IVIWSATNMKWIEAKMKELG VSTNANYKITFMLDSAAMIT VHTPRRGLIDVKPLGVIWGK FSEFYSKKNTIMFDDIGRNF LMNPQNGLKIRPFMKAHLNR DKDKELLKLTQYLKEIAKLD DFLDLNHKYWERYLSKKQGQ |
| Tissue Specificity | Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumor tissues. |
| Function | Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. Recruited to the 19S regulatory particle of the 26S proteasome through its interaction with 19S component PSMD2/RPN1. Once recruited, dephosphorylates 19S component PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly. Has also been reported to stimulate the proteolytic activity of the 26S proteasome. |
| Protein Name | Ubiquitin-Like Domain-Containing Ctd Phosphatase 1Nuclear Proteasome Inhibitor Ublcp1 |
| Cellular Localisation | NucleusColocalizes With Nuclear Proteasomes |
| Alternative Antibody Names | Anti-Ubiquitin-Like Domain-Containing Ctd Phosphatase 1 antibodyAnti-Nuclear Proteasome Inhibitor Ublcp1 antibodyAnti-UBLCP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
