| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UBASH3B |
| Gene ID: | 84959 |
| Uniprot ID: | UBS3B_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human UBASH3B (NP_116262.2). |
| Immunogen Sequence: | MAQYGHPSPLGMAAREELYS KVTPRRNRQQRPGTIKHGSA LDVLLSMGFPRARAQKALAS TGGRSVQAACDWLFSHVGDP FLDDPLPREYVLYLRPTGPL AQKLSDFWQQSKQICGKNKA HNIFPHITLCQFFMCEDSKV DALGEALQTTVSRWKCKFSA PLPLELYTSSNFIGLFVKED SAEVLKKFAADFAAEAASKT EVHVEPHKKQLHVTLAYHFQ ASHLPTLEKLAQNIDVKLG |
| Function | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. |
| Protein Name | Ubiquitin-Associated And Sh3 Domain-Containing Protein BCbl-Interacting Protein P70Suppressor Of T-Cell Receptor Signaling 1Sts-1T-Cell Ubiquitin Ligand 2Tula-2Tyrosine-Protein Phosphatase Sts1/Tula2 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ubiquitin-Associated And Sh3 Domain-Containing Protein B antibodyAnti-Cbl-Interacting Protein P70 antibodyAnti-Suppressor Of T-Cell Receptor Signaling 1 antibodyAnti-Sts-1 antibodyAnti-T-Cell Ubiquitin Ligand 2 antibodyAnti-Tula-2 antibodyAnti-Tyrosine-Protein Phosphatase Sts1/Tula2 antibodyAnti-UBASH3B antibodyAnti-KIAA1959 antibodyAnti-STS1 antibody |
Information sourced from Uniprot.org