| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UBA2 (60-160) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UBA2 |
| Gene ID: |
10054 |
| Uniprot ID: |
SAE2_HUMAN |
| Immunogen Region: |
60-160 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 60-160 of human UBA2 (NP_005490.1). |
| Immunogen Sequence: |
QFLFQKKHVGRSKAQVAKES VLQFYPKANIVAYHDSIMNP DYNVEFFRQFILVMNALDNR AARNHVNRMCLAADVPLIES GTAGYLGQVTTIKKGVTECY E |
| Post Translational Modifications | Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-236 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking. |
| Function | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. |
| Protein Name | Sumo-Activating Enzyme Subunit 2Anthracycline-Associated Resistance ArxUbiquitin-Like 1-Activating Enzyme E1bUbiquitin-Like Modifier-Activating Enzyme 2 |
| Database Links | Reactome: R-HSA-3065676Reactome: R-HSA-3065678 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Cytoplasm And The NucleusSumoylation Is Required Either For Nuclear Translocation Or Nuclear Retention |
| Alternative Antibody Names | Anti-Sumo-Activating Enzyme Subunit 2 antibodyAnti-Anthracycline-Associated Resistance Arx antibodyAnti-Ubiquitin-Like 1-Activating Enzyme E1b antibodyAnti-Ubiquitin-Like Modifier-Activating Enzyme 2 antibodyAnti-UBA2 antibodyAnti-SAE2 antibodyAnti-UBLE1B antibodyAnti-HRIHFB2115 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
