| Post Translational Modifications | Sumoylated with SUMO1 and SUMO2/3 and by UBC9. Sumoylation at Lys-236 inhibits enzymatic activity. Sumoylation at the C-terminal lysine cluster plays an essential role in nuclear trafficking. |
| Function | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. |
| Protein Name | Sumo-Activating Enzyme Subunit 2Anthracycline-Associated Resistance ArxUbiquitin-Like 1-Activating Enzyme E1bUbiquitin-Like Modifier-Activating Enzyme 2 |
| Database Links | Reactome: R-HSA-3065676Reactome: R-HSA-3065678 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Cytoplasm And The NucleusSumoylation Is Required Either For Nuclear Translocation Or Nuclear Retention |
| Alternative Antibody Names | Anti-Sumo-Activating Enzyme Subunit 2 antibodyAnti-Anthracycline-Associated Resistance Arx antibodyAnti-Ubiquitin-Like 1-Activating Enzyme E1b antibodyAnti-Ubiquitin-Like Modifier-Activating Enzyme 2 antibodyAnti-UBA2 antibodyAnti-SAE2 antibodyAnti-UBLE1B antibodyAnti-HRIHFB2115 antibody |
Information sourced from Uniprot.org
