• Western blot analysis using Tyro3 monoclonal antibody against extracellular domain of human Tyro3 (aa41-429).

Anti-TYRO3 antibody [10E11] (STJ98443)

SKU:
STJ98443

Current Stock:
Host: Mouse
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Tyrosine-protein kinase receptor TYRO3 is suitable for use in Western Blot and ELISA research applications.
Clonality: Monoclonal
Clone ID: 10E11
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TYRO3
Gene ID: 7301
Uniprot ID: TYRO3_HUMAN
Specificity: Tyro3 Monoclonal Antibody detects endogenous levels of Tyro3 protein.
Immunogen: Purified recombinant extracellular fragment of human Tyro3 fused with hIgGFc tag expressed in HEK293 cell line.
Post Translational Modifications Autophosphorylated.
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.
Protein Name Tyrosine-Protein Kinase Receptor Tyro3
Tyrosine-Protein Kinase Byk
Tyrosine-Protein Kinase Dtk
Tyrosine-Protein Kinase Rse
Tyrosine-Protein Kinase Sky
Tyrosine-Protein Kinase Tif
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Tyrosine-Protein Kinase Receptor Tyro3 antibody
Anti-Tyrosine-Protein Kinase Byk antibody
Anti-Tyrosine-Protein Kinase Dtk antibody
Anti-Tyrosine-Protein Kinase Rse antibody
Anti-Tyrosine-Protein Kinase Sky antibody
Anti-Tyrosine-Protein Kinase Tif antibody
Anti-TYRO3 antibody
Anti-BYK antibody
Anti-DTK antibody
Anti-RSE antibody
Anti-SKY antibody
Anti-TIF antibody

Information sourced from Uniprot.org

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