| Function | Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7. |
| Protein Name | Tetraspanin-33Tspan-33PenumbraHpenProerythroblast New Membrane |
| Database Links | Reactome: R-HSA-977225 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell JunctionAdherens JunctionCytoplasmIs Localized To Zonula Adherens By Plekha7 By A Pdzd11-Dependent Interaction |
| Alternative Antibody Names | Anti-Tetraspanin-33 antibodyAnti-Tspan-33 antibodyAnti-Penumbra antibodyAnti-Hpen antibodyAnti-Proerythroblast New Membrane antibodyAnti-TSPAN33 antibodyAnti-PEN antibody |
Information sourced from Uniprot.org
