Host: |
Rabbit |
Applications: |
WB/ELISA |
Reactivity: |
Human/Rat/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-TSC22 domain family protein 3 is suitable for use in Western Blot and ELISA research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: |
1 mg/mL |
Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
TSC22D3 |
Gene ID: |
1831 |
Uniprot ID: |
T22D3_HUMAN |
Specificity: |
T22D3 Polyclonal Antibody detects endogenous levels of protein. |
Immunogen: |
Synthesized peptide derived from part of the human protein |
Function | Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities. In vitro, suppresses AP-1 transcription factor complex DNA-binding activities. Isoform 1: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. |
Protein Name | Tsc22 Domain Family Protein 3Dsip-Immunoreactive PeptideProtein DipHdipDelta Sleep-Inducing Peptide ImmunoreactorGlucocorticoid-Induced Leucine Zipper ProteinGilzTsc-22-Like ProteinTsc-22-Related ProteinTsc-22r |
Database Links | Reactome: R-HSA-2672351 |
Cellular Localisation | Isoform 1: CytoplasmNucleusLocalization Depends On Differentiation Status Of MyoblastsIn Undifferentiated MyoblastsLocalizes To The CytoplasmBut In Differentiating MyoblastLocalizes To The Nucleus |
Alternative Antibody Names | Anti-Tsc22 Domain Family Protein 3 antibodyAnti-Dsip-Immunoreactive Peptide antibodyAnti-Protein Dip antibodyAnti-Hdip antibodyAnti-Delta Sleep-Inducing Peptide Immunoreactor antibodyAnti-Glucocorticoid-Induced Leucine Zipper Protein antibodyAnti-Gilz antibodyAnti-Tsc-22-Like Protein antibodyAnti-Tsc-22-Related Protein antibodyAnti-Tsc-22r antibodyAnti-TSC22D3 antibodyAnti-DSIPI antibodyAnti-GILZ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance