| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRPC6 (732-931) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRPC6 |
| Gene ID: |
7225 |
| Uniprot ID: |
TRPC6_HUMAN |
| Immunogen Region: |
732-931 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 732-931 of human TRPC6 (NP_004612.2). |
| Immunogen Sequence: |
QEIEDDADVEWKFARAKLWF SYFEEGRTLPVPFNLVPSPK SLFYLLLKLKKWISELFQGH KKGFQEDAEMNKINEEKKLG ILGSHEDLSKLSLDKKQVGH NKQPSIRSSEDFHLNSFNNP PRQYQKIMKRLIKRYVLQAQ IDKESDEVNEGELKEIKQDI SSLRYELLEEKSQNTEDLAE LIRELGEKLSMEPNQEETNR |
| Tissue Specificity | Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. |
| Post Translational Modifications | Phosphorylated by FYN, leading to an increase of TRPC6 channel activity. |
| Function | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. |
| Protein Name | Short Transient Receptor Potential Channel 6Trpc6Transient Receptor Protein 6Trp-6 |
| Database Links | Reactome: R-HSA-114508Reactome: R-HSA-139853Reactome: R-HSA-3295583Reactome: R-HSA-418890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 6 antibodyAnti-Trpc6 antibodyAnti-Transient Receptor Protein 6 antibodyAnti-Trp-6 antibodyAnti-TRPC6 antibodyAnti-TRP6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
