| Function | E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway. Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2. Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway. Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim35Hemopoietic Lineage Switch Protein 5 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmNucleusFound Predominantly In Cytoplasm With A Granular DistributionFound In Punctuate Nuclear Bodies |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim35 antibodyAnti-Hemopoietic Lineage Switch Protein 5 antibodyAnti-TRIM35 antibodyAnti-HLS5 antibodyAnti-KIAA1098 antibody |
Information sourced from Uniprot.org
