| Host: |
Rabbit |
| Applications: |
WB/IHC/ELISA |
| Reactivity: |
Human |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Tripartite Motif-Containing Protein 34 is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Purification: |
Affinity purification |
| Concentration: |
0.4 mg/mL |
| Dilution Range: |
WB 1:200-1:1000, IHC 1:25-1:100 |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Tissue Specificity | Isoform 1: Is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes. |
| Function | Functions as antiviral protein and contributes to the defense against retroviral infections. Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination. In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis. Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis. Promotes also the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim34Interferon-Responsive Finger Protein 1Ring Finger Protein 21 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmMitochondrionLocalizes In Cytoplasmic Bodies Together With Trim5 And Incoming Hiv-1 Capsids During Infection |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim34 antibodyAnti-Interferon-Responsive Finger Protein 1 antibodyAnti-Ring Finger Protein 21 antibodyAnti-TRIM34 antibodyAnti-IFP1 antibodyAnti-RNF21 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
