| Tissue Specificity | Isoform 1: Is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes. |
| Function | Functions as antiviral protein and contributes to the defense against retroviral infections. Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination. In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis. Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis. Promotes also the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim34Interferon-Responsive Finger Protein 1Ring Finger Protein 21 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmMitochondrionLocalizes In Cytoplasmic Bodies Together With Trim5 And Incoming Hiv-1 Capsids During Infection |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim34 antibodyAnti-Interferon-Responsive Finger Protein 1 antibodyAnti-Ring Finger Protein 21 antibodyAnti-TRIM34 antibodyAnti-IFP1 antibodyAnti-RNF21 antibody |
Information sourced from Uniprot.org
