| Function | E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis. Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2. Plays also a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN. Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS. Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm. Plays also an important regulatory effect on the activation of hepatic stellate cells (HSCs). |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim15Ring Finger Protein 93Zinc Finger Protein 178Zinc Finger Protein B7 |
| Cellular Localisation | CytoplasmNucleusCell JunctionFocal AdhesionLocalizes To Focal Adhesions During The Early Stage Of Adhesion Biogenesis |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim15 antibodyAnti-Ring Finger Protein 93 antibodyAnti-Zinc Finger Protein 178 antibodyAnti-Zinc Finger Protein B7 antibodyAnti-TRIM15 antibodyAnti-RNF93 antibodyAnti-ZNF178 antibodyAnti-ZNFB7 antibody |
Information sourced from Uniprot.org
