| Host: |
Rabbit |
| Applications: |
WB/IHC/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Tripartite Motif-Containing Protein 14 is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Purification: |
Affinity purification |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB 1:500-2000, IHC 1:25-100 |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Tissue Specificity | Highest expression in liver.undetectable in skeletal muscle. |
| Post Translational Modifications | Ubiquitinated. Undergoes 'Lys-63'-linked polyubiquitination.this modification allows IKBKG/NEMO recruitment to MAVS. Undergoes 'Lys-48'-linked polyubiquitination by RNF125.this modification mediates its degradation via the ubiquitin-proteasome pathway. |
| Function | Plays an essential role in the innate immune defense against viruses and bacteria. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation. Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression. Inhibits the transcriptional activity of SPI1 in a dose-dependent manner. |
| Protein Name | Tripartite Motif-Containing Protein 14 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Mitochondrion Outer MembraneCytoplasmic VesiclePhagosome |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 14 antibodyAnti-TRIM14 antibodyAnti-KIAA0129 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
