| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIB1 (203-372) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:4000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIB1 |
| Gene ID: |
10221 |
| Uniprot ID: |
TRIB1_HUMAN |
| Immunogen Region: |
203-372 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 203-372 of human TRIB1 (NP_079471.1). |
| Immunogen Sequence: |
LGDLKLRKFVFSTEERTQLR LESLEDTHIMKGEDDALSDK HGCPAYVSPEILNTTGTYSG KAADVWSLGVMLYTLLVGRY PFHDSDPSALFSKIRRGQFC IPEHISPKARCLIRSLLRRE PSERLTAPEILLHPWFESVL EPGYIDSEIGTSDQIVPEYQ EDSDISSFFC |
| Tissue Specificity | Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow. |
| Function | Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain. Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA. Binds selectively the recognition sequence of CEBPA. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner. Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain. Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity. |
| Protein Name | Tribbles Homolog 1Trb-1G-Protein-Coupled Receptor-Induced Gene 2 ProteinGig-2Skip1 |
| Database Links | Reactome: R-HSA-9031628 |
| Alternative Antibody Names | Anti-Tribbles Homolog 1 antibodyAnti-Trb-1 antibodyAnti-G-Protein-Coupled Receptor-Induced Gene 2 Protein antibodyAnti-Gig-2 antibodyAnti-Skip1 antibodyAnti-TRIB1 antibodyAnti-C8FW antibodyAnti-GIG2 antibodyAnti-TRB1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
