| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TP73 (487-636) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TP73 |
| Gene ID: |
7161 |
| Uniprot ID: |
P73_HUMAN |
| Immunogen Region: |
487-636 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 487-636 of human TP73 (NP_005418.1). |
| Immunogen Sequence: |
YHADPSLVSFLTGLGCPNCI EYFTSQGLQSIYHLQNLTIE DLGALKIPEQYRMTIWRGLQ DLKQGHDYSTAQQLLRSSNA ATISIGGSGELQRQRVMEAV HFRVRHTITIPNRGGPGGGP DEWADFGFDLPDCKARKQPI KEEFTEAEIH |
| Tissue Specificity | Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue. Expressed in the respiratory epithelium. |
| Post Translational Modifications | Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function. Higher levels of phosphorylation seen in the brain from patients with Huntington disease. Polyubiquitinated by RCHY1/PIRH2.leading to its degradation by the proteasome. |
| Function | Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression. It is an essential factor for the positive regulation of lung ciliated cell differentiation. |
| Protein Name | Tumor Protein P73P53-Like Transcription FactorP53-Related Protein |
| Database Links | Reactome: R-HSA-139915Reactome: R-HSA-6803204Reactome: R-HSA-6803205Reactome: R-HSA-6803207Reactome: R-HSA-6803211Reactome: R-HSA-6804759Reactome: R-HSA-8939236 |
| Cellular Localisation | NucleusCytoplasmAccumulates In The Nucleus In Response To Dna Damage |
| Alternative Antibody Names | Anti-Tumor Protein P73 antibodyAnti-P53-Like Transcription Factor antibodyAnti-P53-Related Protein antibodyAnti-TP73 antibodyAnti-P73 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
