| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TOR1A (40-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TOR1A |
| Gene ID: |
1861 |
| Uniprot ID: |
TOR1A_HUMAN |
| Immunogen Region: |
40-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human TorsinA/TOR1A (NP_000104.1). |
| Immunogen Sequence: |
PRLYCLFAECCGQKRSLSRE ALQKDLDDNLFGQHLAKKII LNAVFGFINNPKPKKPLTLS LHGWTGTGKNFVSKIIAENI YEGGLNSDYVHLFVATLHFP HASNITLYKDQLQLWIRGNV SACARSIFIFDEMDKMHAGL IDAIKPFLDYYDLVDGVSYQ KAMFIFLSNAGAERITDVAL DFWRSGKQREDIKLKDIEHA LSVSVFNNKNSGFWHSSLID RNLIDYFVPFLPLEYKHLK |
| Tissue Specificity | Widely expressed. Highest levels in kidney and liver. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also highly expressed in the spinal cord. |
| Post Translational Modifications | N-glycosylated. |
| Function | Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues. |
| Protein Name | Torsin-1aDystonia 1 ProteinTorsin Atpase-1aTorsin Family 1 Member A |
| Database Links | Reactome: R-HSA-8856825 |
| Cellular Localisation | Endoplasmic Reticulum LumenNucleus MembranePeripheral Membrane ProteinCell ProjectionGrowth ConeCytoplasmic Vesicle MembraneCytoplasmic VesicleSecretory VesicleSynaptic VesicleCytoplasmCytoskeletonUpon Oxidative StressRedistributes To Protusions From The Cell SurfacePeripherally Associated With The Inner Face Of The Er MembraneProbably Mediated By The Interaction With Tor1aip1The Association With Nucleus Membrane Is Mediated By The Interaction With Tor1aip2 |
| Alternative Antibody Names | Anti-Torsin-1a antibodyAnti-Dystonia 1 Protein antibodyAnti-Torsin Atpase-1a antibodyAnti-Torsin Family 1 Member A antibodyAnti-TOR1A antibodyAnti-DQ2 antibodyAnti-DYT1 antibodyAnti-TA antibodyAnti-TORA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
