• Western blot analysis of extracts of various cell lines, using TNS4 antibody (STJ111391) at 1:3000 dilution. _Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. _Lysates/proteins: 25ug per lane. _Blocking buffer: 3% non-fat dry milk in TBST. _Detection: ECL Enhanced Kit. _Exposure time: 90s.
  • Western blot analysis of various lysates using TNS4 Rabbit polyclonal antibody (STJ111391) at 1:3000 dilution. _Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. _Lysates/proteins: 25 Mu g per lane. _Blocking buffer: 3% nonfat dry milk in TBST. _Detection: ECL Enhanced Kit. _Exposure time: 90s.

Anti-TNS4 antibody (380-520) (STJ111391)

SKU:
STJ111391

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TNS4 (380-520) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TNS4
Gene ID: 84951
Uniprot ID: TENS4_HUMAN
Immunogen Region: 380-520
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 380-520 of human TNS4 (NP_116254.4).
Immunogen Sequence: CPEPGSSPPQRTPGHQNSVQ PGAASPSNPCPATRSNSQTL SDAPFTTCPEGPARDMQPTM KFVMDTSKYWFKPNITREQA IELLRKEEPGAFVIRDSSSY RGSFGLALKVQEVPASAQSR PGEDSNDLIRHFLIESSAKG V
Tissue Specificity Expressed at low levels in colon (at protein level). Expressed in prostate and placenta.
Post Translational Modifications Proteolytically cleaved by caspase-3 during apoptosis.
Function Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration. Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF. Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration.
Protein Name Tensin-4
C-Terminal Tensin-Like Protein
Database Links Reactome: R-HSA-8875513
Cellular Localisation Cell Junction
Focal Adhesion
Cytoplasm
Cytoskeleton
Alternative Antibody Names Anti-Tensin-4 antibody
Anti-C-Terminal Tensin-Like Protein antibody
Anti-TNS4 antibody
Anti-CTEN antibody
Anti-PP14434 antibody

Information sourced from Uniprot.org

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