| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TNS1 (1-110) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNS1 |
| Gene ID: |
7145 |
| Uniprot ID: |
TENS1_HUMAN |
| Immunogen Region: |
1-110 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human TNS1 (NP_072174.3). |
| Immunogen Sequence: |
MSVSRTMEDSCELDLVYVTE RIIAVSFPSTANEENFRSNL REVAQMLKSKHGGNYLLFNL SERRPDITKLHAKVLEFGWP DLHTPALEKICSICKAMDTW LNADPHNVVV |
| Tissue Specificity | In the lung, detected in the alveolar septa (at protein level). Ubiquitous. |
| Post Translational Modifications | Extensively phosphorylated on serine and threonine residues in a p38 MAPK-dependent manner which reduces interaction with DLC1 and increases interaction with tyrosine-phosphorylated proteins including BCAR1/p130cas and PTK2/FAK. The majority of the phosphorylated Ser/Thr residues are immediately adjacent to a proline residue. Also phosphorylated on tyrosine residues. Rapidly cleaved by calpain II. |
| Function | May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation. Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition. Enhances RHOA activation in the presence of DLC1. Plays a role in cell polarization and migration. May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton. |
| Protein Name | Tensin-1 |
| Cellular Localisation | Cell SurfaceCell JunctionFocal AdhesionCytoplasmCytoskeletonLocalizes To Both Focal Adhesions And Fibrillar AdhesionsLocalized At The Cell Periphery Preferentially To Fibrillar Adhesions Rather Than To Focal AdhesionsTranslocates From The Cell Edge To The Cell Center In An Itgb1bp1-Dependent Manner |
| Alternative Antibody Names | Anti-Tensin-1 antibodyAnti-TNS1 antibodyAnti-TNS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
