| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Transportin-3 (601-651) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNPO3 |
| Gene ID: |
23534 |
| Uniprot ID: |
TNPO3_HUMAN |
| Immunogen Region: |
601-651 |
| Specificity: |
This antibody detects endogenous levels of human TNPO3 |
| Immunogen: |
Synthesized peptide derived from human TNPO3 AA range: 601-651 |
| Function | Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus. (Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus. Required for a nuclear maturation step of HIV-1 prior to integration. |
| Protein Name | Transportin-3Importin-12Imp12Transportin-SrTrn-Sr |
| Cellular Localisation | Nucleus EnvelopeCytoplasmLocalizes To The Nuclear Envelope And Annulate LamellaeWhich Consists In Stacks Of Endoplasmic Reticulum Membranes Containing A High Density Of Nuclear Pores |
| Alternative Antibody Names | Anti-Transportin-3 antibodyAnti-Importin-12 antibodyAnti-Imp12 antibodyAnti-Transportin-Sr antibodyAnti-Trn-Sr antibodyAnti-TNPO3 antibodyAnti-IPO12 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
