| Function | Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus. (Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus. Required for a nuclear maturation step of HIV-1 prior to integration. |
| Protein Name | Transportin-3Importin-12Imp12Transportin-SrTrn-Sr |
| Cellular Localisation | Nucleus EnvelopeCytoplasmLocalizes To The Nuclear Envelope And Annulate LamellaeWhich Consists In Stacks Of Endoplasmic Reticulum Membranes Containing A High Density Of Nuclear Pores |
| Alternative Antibody Names | Anti-Transportin-3 antibodyAnti-Importin-12 antibodyAnti-Imp12 antibodyAnti-Transportin-Sr antibodyAnti-Trn-Sr antibodyAnti-TNPO3 antibodyAnti-IPO12 antibody |
Information sourced from Uniprot.org
