| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNPO1 |
| Gene ID: | 3842 |
| Uniprot ID: | TNPO1_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 800 to the C-terminus of human TNPO1 (NP_002261.3). |
| Immunogen Sequence: | QFIRPWCTSLRNIRDNEEKD SAFRGICTMISVNPSGVIQD FIFFCDAVASWINPKDDLRD MFCKILHGFKNQVGDENWRR FSDQFPLPLKERLAAFYGV |
| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates nuclear import of SRP19. Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner. Main mediator of PR-DUB complex component BAP1 nuclear import.acts redundantly with the karyopherins KPNA1 and KPNA2. (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. |
| Protein Name | Transportin-1 Importin Beta-2 Karyopherin Beta-2 M9 Region Interaction Protein Mip |
| Database Links | Reactome: R-HSA-450513 Reactome: R-HSA-5620924 Reactome: R-HSA-9615933 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Transportin-1 antibody Anti-Importin Beta-2 antibody Anti-Karyopherin Beta-2 antibody Anti-M9 Region Interaction Protein antibody Anti-Mip antibody Anti-TNPO1 antibody Anti-KPNB2 antibody Anti-MIP1 antibody Anti-TRN antibody |
Information sourced from Uniprot.org