| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNKS |
| Gene ID: | 8658 |
| Uniprot ID: | TNKS1_HUMAN |
| Immunogen Region: | 1050-1150 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human TNKS (NP_003738.2). |
| Immunogen Sequence: | EQITLDVLADMGHEELKEIG INAYGHRHKLIKGVERLLGG QQGTNPYLTFHCVNQGTILL DLAPEDKEYQSVEEEMQSTI REHRDGGNAGGIFNRYNVIR I |
| Tissue Specificity | Ubiquitous.highest levels in testis. |
| Post Translational Modifications | Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. Phosphorylated during mitosis. Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation. Deubiquitinated by USP25.leading to stabilization. ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. |
| Function | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity. |
| Protein Name | Poly Adp-Ribose Polymerase Tankyrase-1 Adp-Ribosyltransferase Diphtheria Toxin-Like 5 Artd5 Poly Adp-Ribose Polymerase 5a Protein Poly-Adp-Ribosyltransferase Tankyrase-1 Tnks-1 Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase Tankyrase I Tankyrase-1 Tank1 |
| Database Links | Reactome: R-HSA-201681 Reactome: R-HSA-4641257 Reactome: R-HSA-5545619 Reactome: R-HSA-5689880 Reactome: R-HSA-8948751 |
| Cellular Localisation | Cytoplasm Golgi Apparatus Membrane Peripheral Membrane Protein Cytoskeleton Microtubule Organizing Center Centrosome Nucleus Nuclear Pore Complex Chromosome Telomere Spindle Pole Associated With The Golgi And With Juxtanuclear Slc2a4/Glut4-Vesicles A Minor Proportion Is Also Found At Nuclear Pore Complexes And Around The Pericentriolar Matrix Of Mitotic Centromeres During Interphase A Small Fraction Of Tnks Is Found In The Nucleus Associated With Terf1 Localizes To Spindle Poles At Mitosis Onset Via Interaction With Numa1 |
| Alternative Antibody Names | Anti-Poly Adp-Ribose Polymerase Tankyrase-1 antibody Anti-Adp-Ribosyltransferase Diphtheria Toxin-Like 5 antibody Anti-Artd5 antibody Anti-Poly Adp-Ribose Polymerase 5a antibody Anti-Protein Poly-Adp-Ribosyltransferase Tankyrase-1 antibody Anti-Tnks-1 antibody Anti-Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase antibody Anti-Tankyrase I antibody Anti-Tankyrase-1 antibody Anti-Tank1 antibody Anti-TNKS antibody Anti-PARP5A antibody Anti-PARPL antibody Anti-TIN1 antibody Anti-TINF1 antibody Anti-TNKS1 antibody |
Information sourced from Uniprot.org