| Tissue Specificity | Expressed in T-cells, B-cells, macrophages, neurons in the brain and brainstem, and stratified squamous epithelia of the esophagus, cervix and skin. |
| Post Translational Modifications | Phosphorylated by TAK1/MAP3K7.this phosphorylation triggers association with BTRC and subsequent ubiquitination and degradation. Ubiquitinated in a BTRC-depdent manner.leading to degradation mediated through the proteasome pathway. |
| Function | Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression. Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness. Inhibits also autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex. Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity. Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells. |
| Protein Name | Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 2Tipe2Tnf Alpha-Induced Protein 8-Like Protein 2Tnfaip8-Like Protein 2Inflammation Factor Protein 20 |
| Database Links | Reactome: R-HSA-1483255 |
| Cellular Localisation | CytoplasmNucleusLysosome |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 2 antibodyAnti-Tipe2 antibodyAnti-Tnf Alpha-Induced Protein 8-Like Protein 2 antibodyAnti-Tnfaip8-Like Protein 2 antibodyAnti-Inflammation Factor Protein 20 antibodyAnti-TNFAIP8L2 antibody |
Information sourced from Uniprot.org
