| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TNFAIP8 (1-198) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNFAIP8 |
| Gene ID: |
25816 |
| Uniprot ID: |
TFIP8_HUMAN |
| Immunogen Region: |
1-198 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human TNFAIP8 (NP_055165.2). |
| Immunogen Sequence: |
MHSEAEESKEVATDVFNSKN LAVQAQKKILGKMVSKSIAT TLIDDTSSEVLDELYRVTRE YTQNKKEAEKIIKNLIKTVI KLAILYRNNQFNQDELALME KFKKKVHQLAMTVVSFHQVD YTFDRNVLSRLLNECREMLH QIIQRHLTAKSHGRVNNVFD HFSDCEFLAALYNPFGNFKP HLQKLCDGINKMLDEENI |
| Tissue Specificity | Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle. |
| Function | Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. |
| Protein Name | Tumor Necrosis Factor Alpha-Induced Protein 8Tnf Alpha-Induced Protein 8Head And Neck Tumor And Metastasis-Related ProteinMdc-3.13Nf-Kappa-B-Inducible Ded-Containing ProteinNdedScc-S2Tnf-Induced Protein Gg2-1 |
| Database Links | Reactome: R-HSA-1483255 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Alpha-Induced Protein 8 antibodyAnti-Tnf Alpha-Induced Protein 8 antibodyAnti-Head And Neck Tumor And Metastasis-Related Protein antibodyAnti-Mdc-3.13 antibodyAnti-Nf-Kappa-B-Inducible Ded-Containing Protein antibodyAnti-Nded antibodyAnti-Scc-S2 antibodyAnti-Tnf-Induced Protein Gg2-1 antibodyAnti-TNFAIP8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
