| Tissue Specificity | Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle. |
| Function | Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. |
| Protein Name | Tumor Necrosis Factor Alpha-Induced Protein 8Tnf Alpha-Induced Protein 8Head And Neck Tumor And Metastasis-Related ProteinMdc-3.13Nf-Kappa-B-Inducible Ded-Containing ProteinNdedScc-S2Tnf-Induced Protein Gg2-1 |
| Database Links | Reactome: R-HSA-1483255 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Alpha-Induced Protein 8 antibodyAnti-Tnf Alpha-Induced Protein 8 antibodyAnti-Head And Neck Tumor And Metastasis-Related Protein antibodyAnti-Mdc-3.13 antibodyAnti-Nf-Kappa-B-Inducible Ded-Containing Protein antibodyAnti-Nded antibodyAnti-Scc-S2 antibodyAnti-Tnf-Induced Protein Gg2-1 antibodyAnti-TNFAIP8 antibody |
Information sourced from Uniprot.org
