Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-TMPRSS11D (42-292) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | TMPRSS11D |
Gene ID: | 9407 |
Uniprot ID: | TM11D_HUMAN |
Immunogen Region: | 42-292 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-292 of human TMPRSS11D (NP_004253.1). |
Immunogen Sequence: | AFDQKSYFYRSSFQLLNVEY NSQLNSPATQEYRTLSGRIE SLITKTFKESNLRNQFIRAH VAKLRQDGSGVRADVVMKFQ FTRNNNGASMKSRIESVLRQ MLNNSGNLEINPSTEITSLT DQAAANWLINECGAGPDLIT LSEQRILGGTEAEEGSWPWQ VSLRLNNAHHCGGSLINNMW ILTAAHCFRSNSNPRDWIAT SGISTTFPKLRMRVRNILIH NNYKSATHENDIALVRLEN |
Tissue Specificity | Located in the cells of the submucosal serous glands of the bronchi and trachea. |
Function | May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions.spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate. |
Protein Name | Transmembrane Protease Serine 11d Airway Trypsin-Like Protease Cleaved Into - Transmembrane Protease Serine 11d Non-Catalytic Chain - Transmembrane Protease Serine 11d Catalytic Chain |
Cellular Localisation | Cell Membrane Single-Pass Type Ii Membrane Protein Activated By Cleavage And Secreted Transmembrane Protease Serine 11d Catalytic Chain: Secreted |
Alternative Antibody Names | Anti-Transmembrane Protease Serine 11d antibody Anti-Airway Trypsin-Like Protease Cleaved Into - Transmembrane Protease Serine 11d Non-Catalytic Chain - Transmembrane Protease Serine 11d Catalytic Chain antibody Anti-TMPRSS11D antibody Anti-HAT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance