| Tissue Specificity | Located in the cells of the submucosal serous glands of the bronchi and trachea. |
| Function | May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions.spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate. |
| Protein Name | Transmembrane Protease Serine 11dAirway Trypsin-Like Protease Cleaved Into - Transmembrane Protease Serine 11d Non-Catalytic Chain - Transmembrane Protease Serine 11d Catalytic Chain |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinActivated By Cleavage And SecretedTransmembrane Protease Serine 11d Catalytic Chain: Secreted |
| Alternative Antibody Names | Anti-Transmembrane Protease Serine 11d antibodyAnti-Airway Trypsin-Like Protease Cleaved Into - Transmembrane Protease Serine 11d Non-Catalytic Chain - Transmembrane Protease Serine 11d Catalytic Chain antibodyAnti-TMPRSS11D antibodyAnti-HAT antibody |
Information sourced from Uniprot.org
