| Post Translational Modifications | N-glycosylated. |
| Function | Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. |
| Protein Name | Transmembrane Protein 59Liver Membrane-Bound Protein |
| Database Links | Reactome: R-HSA-9013407Reactome: R-HSA-9696273 |
| Cellular Localisation | Late Endosome MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneCell MembraneGolgi Apparatus MembraneMainly Localizes To Late Endosomes/LysosomesProbably First Exported To The Cell Surface And Then Actively Endocytosed To Transiently Localize In Early Endosomes On Its Way To The Late Endosomal/Lysosomal Compartment Where It Becomes Quickly Degraded |
| Alternative Antibody Names | Anti-Transmembrane Protein 59 antibodyAnti-Liver Membrane-Bound Protein antibodyAnti-TMEM59 antibodyAnti-C1orf8 antibodyAnti-HSPC001 antibodyAnti-UNQ169 antibodyAnti-PRO195 antibody |
Information sourced from Uniprot.org
