| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TM4SF19 |
| Gene ID: | 116211 |
| Uniprot ID: | T4S19_HUMAN |
| Immunogen Region: | 50-150 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TM4SF19 (NP_001191827.1). |
| Immunogen Sequence: | LLGRHAMLGTGLWGGGLMVL TALLSGGLALLGALICFVTS GVALKDGPFCMFDVSSFNQT QAWKYGYPFKDLHSRNYLYD RSLWNSVCLEPSAAVVWHVS L |
| Tissue Specificity | In adipose tissue, expressed by macrophages. |
| Function | Negatively regulates vacuolar (H+)-ATPase (V-ATPase) activity by interacting with members of V-ATPase V0 complex and hence inhibiting V1-V0 complex assembly. Required for multinucleation during osteoclast differentiation. |
| Protein Name | Transmembrane 4 L6 Family Member 19Osteoclast Maturation-Associated Gene 4 ProteinTetraspan Membrane Protein Octm4 |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinCytoplasmCytoskeletonCell ProjectionFilopodiumIn OsteoclastsLocalizes Not Only To The Actin RingBut Also To The FilopodiaThe Stretched Structures For Searching Cells To FuseAnd The FusopodThe Cytoplasmic Bridge For Contacting Other Osteoclasts To Fuse |
| Alternative Antibody Names | Anti-Transmembrane 4 L6 Family Member 19 antibodyAnti-Osteoclast Maturation-Associated Gene 4 Protein antibodyAnti-Tetraspan Membrane Protein Octm4 antibodyAnti-TM4SF19 antibodyAnti-OCTM4 antibody |
Information sourced from Uniprot.org