| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TLR1 (30-290) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TLR1 |
| Gene ID: |
7096 |
| Uniprot ID: |
TLR1_HUMAN |
| Immunogen Region: |
30-290 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-290 of human TLR1 (NP_003254.2). |
| Immunogen Sequence: |
DRSKNGLIHVPKDLSQKTTI LNISQNYISELWTSDILSLS KLRILIISHNRIQYLDISVF KFNQELEYLDLSHNKLVKIS CHPTVNLKHLDLSFNAFDAL PICKEFGNMSQLKFLGLSTT HLEKSSVLPIAHLNISKVLL VLGETYGEKEDPEGLQDFNT ESLHIVFPTNKEFHFILDVS VKTVANLELSNIKCVLEDNK CSYFLSILAKLQTNPKLSNL TLNNIETTWNSFIRILQLV |
| Tissue Specificity | Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. |
| Function | Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. |
| Protein Name | Toll-Like Receptor 1Toll/Interleukin-1 Receptor-Like ProteinTilCd Antigen Cd281 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-1461957Reactome: R-HSA-166058Reactome: R-HSA-168179Reactome: R-HSA-5602498Reactome: R-HSA-5603041Reactome: R-HSA-5686938Reactome: R-HSA-9705671 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmic VesiclePhagosome MembraneMembrane RaftGolgi ApparatusDoes Not Reside In Lipid Rafts Before Stimulation But Accumulates Increasingly In The Raft Upon The Presence Of The Microbial LigandIn Response To Triacylated LipoproteinsTlr2:Tlr1 Heterodimers Are Recruited In Lipid RaftsThis Recruitment Determine The Intracellular Targeting To The Golgi Apparatus |
| Alternative Antibody Names | Anti-Toll-Like Receptor 1 antibodyAnti-Toll/Interleukin-1 Receptor-Like Protein antibodyAnti-Til antibodyAnti-Cd Antigen Cd281 antibodyAnti-TLR1 antibodyAnti-KIAA0012 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
