| Tissue Specificity | Widely expressed. Expressed in endothelial cells and in peripheral neurons (at protein level). Isoform 3: Not expressed in fetal neocortex. Isoform 4: Expressed in fetal neocortex. |
| Function | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Isoform 4: During fetal neocortex development, may be essential to maintain the full number of basal radial glia (bRG). bRG are neural progenitor cells that undergo asymmetric divisions, generating a bRG (self-renewal) and a neuron, in contrast to basal intermediate progenitors (bIPs), which typically divide once to give rise to 2 neurons. bRG generate more cortical neurons over time than bIPs. |
| Protein Name | Transketolase-Like Protein 1Transketolase 2Tk 2Transketolase-Related Protein |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Transketolase-Like Protein 1 antibodyAnti-Transketolase 2 antibodyAnti-Tk 2 antibodyAnti-Transketolase-Related Protein antibodyAnti-TKTL1 antibodyAnti-TKR antibodyAnti-TKT2 antibody |
Information sourced from Uniprot.org
