| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TIPIN (1-301) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TIPIN |
| Gene ID: |
54962 |
| Uniprot ID: |
TIPIN_HUMAN |
| Immunogen Region: |
1-301 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human TIPIN (NP_060328.2). |
| Immunogen Sequence: |
MLEPQENGVIDLPDYEHVED ETFPPFPPPASPERQDGEGT EPDEESGNGAPVPVPPKRTV KRNIPKLDAQRLISERGLPA LRHVFDKAKFKGKGHEAEDL KMLIRHMEHWAHRLFPKLQF EDFIDRVEYLGSKKEVQTCL KRIRLDLPILHEDFVSNNDE VAENNEHDVTSTELDPFLTN LSESEMFASELSRSLTEEQQ QRIERNKQLALERRQAKLLS NSQTLGNDMLMNTPRAHTV |
| Function | Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. |
| Protein Name | Timeless-Interacting Protein |
| Database Links | Reactome: R-HSA-5693607 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Timeless-Interacting Protein antibodyAnti-TIPIN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
