| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:4000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TIMM50 |
| Gene ID: | 92609 |
| Uniprot ID: | TIM50_HUMAN |
| Immunogen Region: | 190-456 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-456 of human TIMM50 (NP_001001563.1). |
| Immunogen Sequence: | GNNPVDENGAKIPDEFDNDP ILVQQLRRTYKYFKDYRQMI IEPTSPCLLPDPLQEPYYQP PYTLVLELTGVLLHPEWSLA TGWRFKKRPGIETLFQQLAP LYEIVIFTSETGMTAFPLID SVDPHGFISYRLFRDATRYM DGHHVKDISCLNRDPARVVV VDCKKEAFRLQPYNGVALRP WDGNSDDRVLLDLSAFLKTI ALNGVEDVRTVLEHYALEDD PLAAFKQRQSRLEQEEQQR |
| Tissue Specificity | Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level). |
| Function | Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro.however such activity may not be relevant in vivo. Isoform 2: May participate in the release of snRNPs and SMN from the Cajal body. |
| Protein Name | Mitochondrial Import Inner Membrane Translocase Subunit Tim50 |
| Database Links | Reactome: R-HSA-1268020 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane ProteinIsoform 2: Nucleus SpeckleNuclear And Enriched In Speckles With Snrnps |
| Alternative Antibody Names | Anti-Mitochondrial Import Inner Membrane Translocase Subunit Tim50 antibodyAnti-TIMM50 antibodyAnti-TIM50 antibodyAnti-PRO1512 antibody |
Information sourced from Uniprot.org