| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TIE1 |
| Gene ID: | 7075 |
| Uniprot ID: | TIE1_HUMAN |
| Immunogen Region: | 350-600 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-600 of human TIE1 (NP_005415.1). |
| Immunogen Sequence: | IPQILNMASELEFNLETMPR INCAAAGNPFPVRGSIELRK PDGTVLLSTKAIVEPEKTTA EFEVPRLVLADSGFWECRVS TSGGQDSRRFKVNVKVPPVP LAAPRLLTKQSRQLVVSPLV SFSGDGPISTVRLHYRPQDS TMDWSTIVVDPSENVTLMNL RPKTGYSVRVQLSRPGEGGE GAWGPPTLMTTDCPEPLLQP WLEGWHVEGTDRLRVSWSLP LVPGPLVGDGFLLRLWDGT |
| Tissue Specificity | Specifically expressed in developing vascular endothelial cells. |
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2. |
| Function | Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. |
| Protein Name | Tyrosine-Protein Kinase Receptor Tie-1 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Tyrosine-Protein Kinase Receptor Tie-1 antibodyAnti-TIE1 antibodyAnti-TIE antibody |
Information sourced from Uniprot.org