| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-THEM4 (37-150) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
THEM4 |
| Gene ID: |
117145 |
| Uniprot ID: |
THEM4_HUMAN |
| Immunogen Region: |
37-150 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 37-150 of human THEM4 (NP_444283.2). |
| Immunogen Sequence: |
SSEEVILKDCSVPNPSWNKD LRLLFDQFMKKCEDGSWKRL PSYKRTPTEWIQDFKTHFLD PKLMKEEQMSQAQLFTRSFD DGLGFEYVMFYNDIEKRMVC LFQGGPYLEGPPGF |
| Tissue Specificity | Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. |
| Post Translational Modifications | Phosphorylated. |
| Function | Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. inhibits AKT1 phosphorylation and activity. enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. |
| Protein Name | Acyl-Coenzyme A Thioesterase Them4Acyl-Coa Thioesterase Them4Carboxyl-Terminal Modulator ProteinThioesterase Superfamily Member 4 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-165158Reactome: R-HSA-199418Reactome: R-HSA-389357Reactome: R-HSA-5218920Reactome: R-HSA-77289 |
| Cellular Localisation | Cell MembraneCell ProjectionRuffle MembraneCytoplasmMitochondrionMitochondrion Inner MembranePeripheral Membrane ProteinMitochondrion Intermembrane SpaceReleased From The Mitochondria Into The Cytosol In Response To Apoptotic Stimuli |
| Alternative Antibody Names | Anti-Acyl-Coenzyme A Thioesterase Them4 antibodyAnti-Acyl-Coa Thioesterase Them4 antibodyAnti-Carboxyl-Terminal Modulator Protein antibodyAnti-Thioesterase Superfamily Member 4 antibodyAnti-THEM4 antibodyAnti-CTMP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
