| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-THBS4 (27-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
THBS4 |
| Gene ID: |
7060 |
| Uniprot ID: |
TSP4_HUMAN |
| Immunogen Region: |
27-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 27-300 of human THBS4 (NP_003239.2). |
| Immunogen Sequence: |
TPQVFDLLPSSSQRLNPGAL LPVLTDPALNDLYVISTFKL QTKSSATIFGLYSSTDNSKY FEFTVMGRLNKAILRYLKND GKVHLVVFNNLQLADGRRHR ILLRLSNLQRGAGSLELYLD CIQVDSVHNLPRAFAGPSQK PETIELRTFQRKPQDFLEEL KLVVRGSLFQVASLQDCFLQ QSEPLAATGTGDFNRQFLGQ MTQLNQLLGEVKDLLRQQVK ETSFLRNTIAECQACGPLK |
| Function | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner. |
| Protein Name | Thrombospondin-4 |
| Database Links | Reactome: R-HSA-186797 |
| Cellular Localisation | Endoplasmic ReticulumSarcoplasmic ReticulumSecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Thrombospondin-4 antibodyAnti-THBS4 antibodyAnti-TSP4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
