| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TGM3 |
| Gene ID: | 7053 |
| Uniprot ID: | TGM3_HUMAN |
| Immunogen Region: | 291-480 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 291-480 of human TGM3 (NP_003236.3). |
| Immunogen Sequence: | SRVITNFNSAHDTDRNLSVD VYYDPMGNPLDKGSDSVWNF HVWNEGWFVRSDLGPSYGGW QVLDATPQERSQGVFQCGPA SVIGVREGDVQLNFDMPFIF AEVNADRITWLYDNTTGKQW KNSVNSHTIGRYISTKAVGS NARMDVTDKYKYPEGSDQER QVFQKALGKLKPNTPFAATS SMGLETEEQE |
| Post Translational Modifications | Activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease. Dispase cleavage site was proposed to lie between Ser-470 and Ser-471 or between Pro-465 and Phe-466. Physiological activation may be catalyzed by CTSL and, to a lesser extent, by CTSS, but not by CTSB, CTSD nor CTSV. |
| Function | Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. |
| Protein Name | Protein-Glutamine Gamma-Glutamyltransferase E Transglutaminase E Tg(E Tge Tgase E Transglutaminase-3 Tgase-3 Cleaved Into - Protein-Glutamine Gamma-Glutamyltransferase E 50 Kda Catalytic Chain - Protein-Glutamine Gamma-Glutamyltransferase E 27 Kda Non-Catalytic Chain |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Protein-Glutamine Gamma-Glutamyltransferase E antibody Anti-Transglutaminase E antibody Anti-Tg(E antibody Anti-Tge antibody Anti-Tgase E antibody Anti-Transglutaminase-3 antibody Anti-Tgase-3 Cleaved Into - Protein-Glutamine Gamma-Glutamyltransferase E 50 Kda Catalytic Chain - Protein-Glutamine Gamma-Glutamyltransferase E 27 Kda Non-Catalytic Chain antibody Anti-TGM3 antibody |
Information sourced from Uniprot.org