| Host: | Rabbit |
| Applications: | WB/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Transforming growth factor beta receptor type 3 (801-850 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC 1:100-1:300 ELISA 1:5000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TGFBR3 |
| Gene ID: | 7049 |
| Uniprot ID: | TGBR3_HUMAN |
| Immunogen Region: | 801-850 aa |
| Specificity: | TGF Beta RIII Polyclonal Antibody detects endogenous levels of TGF Beta RIII protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human TGF beta Receptor III at the amino acid range 801-850 |
| Function | Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B. In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility. Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization. Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway. (Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL. |
| Protein Name | Transforming Growth Factor Beta Receptor Type 3 Tgf-Beta Receptor Type 3 Tgfr-3 Betaglycan Transforming Growth Factor Beta Receptor Iii Tgf-Beta Receptor Type Iii |
| Database Links | Reactome: R-HSA-1502540 Reactome: R-HSA-190370 Reactome: R-HSA-190373 Reactome: R-HSA-201451 Reactome: R-HSA-2173789 Reactome: R-HSA-9839383 Reactome: R-HSA-9839389 Reactome: R-HSA-9839394 Reactome: R-HSA-9839397 Reactome: R-HSA-9839406 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Secreted Extracellular Space Extracellular Matrix Exists Both As A Membrane-Bound Form And As Soluble Form In Serum And In The Extracellular Matrix |
| Alternative Antibody Names | Anti-Transforming Growth Factor Beta Receptor Type 3 antibody Anti-Tgf-Beta Receptor Type 3 antibody Anti-Tgfr-3 antibody Anti-Betaglycan antibody Anti-Transforming Growth Factor Beta Receptor Iii antibody Anti-Tgf-Beta Receptor Type Iii antibody Anti-TGFBR3 antibody |
Information sourced from Uniprot.org