• Western blot analysis of extracts of mouse skeletal muscle, using TFAP2B antibody (STJ115824) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-TFAP2B antibody (1-160) (STJ115824)

SKU:
STJ115824

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TFAP2B (1-160) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TFAP2B
Gene ID: 7021
Uniprot ID: AP2B_HUMAN
Immunogen Region: 1-160
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TFAP2B (NP_003212.2).
Immunogen Sequence: MHSPPRDQAAIMLWKLVENV KYEDIYEDRHDGVPSHSSRL SQLGSVSQGPYSSAPPLSHT PSSDFQPPYFPPPYQPLPYH QSQDPYSHVNDPYSLNPLHQ PQQHPWGQRQRQEVGSEAGS LLPQPRAALPQLSGLDPRRD YHSVRRPDVLLHSAHHGLDA
Post Translational Modifications Sumoylated on Lys-21.which inhibits transcriptional activity.
Function Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
Protein Name Transcription Factor Ap-2-Beta
Ap2-Beta
Activating Enhancer-Binding Protein 2-Beta
Database Links Reactome: R-HSA-3232118
Reactome: R-HSA-8866904
Reactome: R-HSA-8866907
Reactome: R-HSA-8866910
Cellular Localisation Nucleus
In The Brain
Localizes To The Arcuate Hypothalamic Nucleus
The Ventromedial Hypothalamic Nucleus And The Accumbens Nucleus Of The Ventral Striatum
Alternative Antibody Names Anti-Transcription Factor Ap-2-Beta antibody
Anti-Ap2-Beta antibody
Anti-Activating Enhancer-Binding Protein 2-Beta antibody
Anti-TFAP2B antibody

Information sourced from Uniprot.org

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