Anti-TDG antibody (141-410) (STJ115328)

SKU:
STJ115328

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TDG (141-410) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TDG
Gene ID: 6996
Uniprot ID: TDG_HUMAN
Immunogen Region: 141-410
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 141-410 of human TDG (NP_003202.3).
Immunogen Sequence: PGLMAAYKGHHYPGPGNHFW KCLFMSGLSEVQLNHMDDHT LPGKYGIGFTNMVERTTPGS KDLSSKEFREGGRILVQKLQ KYQPRIAVFNGKCIYEIFSK EVFGVKVKNLEFGLQPHKIP DTETLCYVMPSSSARCAQFP RAQDKVHYYIKLKDLRDQLK GIERNMDVQEVQYTFDLQLA QEDAKKMAVKEEKYDPGYEA AYGGAYGENPCSSEPCGFSS NGLIESVELRGESAFSGIP
Post Translational Modifications Sumoylation on Lys-330 by either SUMO1 or SUMO2 induces dissociation of the product DNA.
Function DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
Protein Name G/T Mismatch-Specific Thymine Dna Glycosylase
Thymine-Dna Glycosylase
Htdg
Database Links Reactome: R-HSA-110328
Reactome: R-HSA-110329
Reactome: R-HSA-110357
Reactome: R-HSA-3108214
Reactome: R-HSA-5221030
Cellular Localisation Nucleus
Alternative Antibody Names Anti-G/T Mismatch-Specific Thymine Dna Glycosylase antibody
Anti-Thymine-Dna Glycosylase antibody
Anti-Htdg antibody
Anti-TDG antibody

Information sourced from Uniprot.org

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