| Background | T cell receptor (TCR) is a heterodimer consisting of an Alpha and a Beta chain (TCR Alpha/Beta ) or a Gamma and a Delta chain (TCR Gamma/Delta ). TCR Gamma/Delta belongs to the immunoglobulin superfamily, which is involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. Gamma/Delta TCR associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most Gamma/Delta T cells are CD4-/CD8-although some are CD8+. T cells expressing the Gamma/Delta TCR have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that Gamma/Delta T cells also play a principal role in antigen presentation. |
Information sourced from Uniprot.org
