| Host: |
Mouse |
| Applications: |
FC |
| Reactivity: |
Human |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-TCR Gamma/Delta is suitable for use in Flow Cytometry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
B1 |
| Conjugation: |
FITC |
| Isotype: |
IgG1k |
| Formulation: |
PBS with 0.05% Proclin300, 1% BSA |
| Storage Instruction: |
Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
| Background | CD49d is a 150 kD Alpha integrin chain known as Alpha 4 integrin or VLA-4 Alpha chain. It forms a heterodimer with either integrin Beta 1 ( Alpha 4 Beta 1, VLA-4) or Beta 7 ( Alpha 4 Beta 7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. Alpha 4 Beta 7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
