| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TBX6 (1-436) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TBX6 |
| Gene ID: |
6911 |
| Uniprot ID: |
TBX6_HUMAN |
| Immunogen Region: |
1-436 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-436 of human TBX6 (NP_004599.2). |
| Immunogen Sequence: |
MYHPRELYPSLGAGYRLGPA QPGADSSFPPALAEGYRYPE LDTPKLDCFLSGMEAAPRTL AAHPPLPLLPPAMGTEPAPS APEALHSLPGVSLSLENREL WKEFSSVGTEMIITKAGRRM FPACRVSVTGLDPEARYLFL LDVIPVDGARYRWQGRRWEP SGKAEPRLPDRVYIHPDSPA TGAHWMRQPVSFHRVKLTNS TLDPHGHLILHSMHKYQPRI HLVRAAQLCSQHWGGMASF |
| Tissue Specificity | Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also expressed in adult testis, kidney, lung, muscle and thymus. |
| Function | T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia. |
| Protein Name | T-Box Transcription Factor Tbx6T-Box Protein 6 |
| Database Links | Reactome: R-HSA-9793380Reactome: R-HSA-9824272 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-T-Box Transcription Factor Tbx6 antibodyAnti-T-Box Protein 6 antibodyAnti-TBX6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
