| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TAOK1 (430-710) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TAOK1 |
| Gene ID: |
57551 |
| Uniprot ID: |
TAOK1_HUMAN |
| Immunogen Region: |
430-710 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 430-710 of human TAOK1 (NP_065842.1). |
| Immunogen Sequence: |
SHYRNREHFATIRTASLVTR QMQEHEQDSELREQMSGYKR MRRQHQKQLMTLENKLKAEM DEHRLRLDKDLETQRNNFAA EMEKLIKKHQAAMEKEAKVM SNEEKKFQQHIQAQQKKELN SFLESQKREYKLRKEQLKEE LNENQSTPKKEKQEWLSKQK ENIQHFQAEEEANLLRRQRQ YLELECRRFKRRMLLGRHNL EQDLVREELNKRQTQKDLEH AMLLRQHESMQELEFRHLN |
| Tissue Specificity | Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle. |
| Post Translational Modifications | Proteolytically processed by caspase-3 (CASP3). Autophosphorylated. Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2. |
| Function | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system. Also plays a role in the regulation of neuronal migration to the cortical plate. |
| Protein Name | Serine/Threonine-Protein Kinase Tao1Kinase From Chicken Homolog BHkfc-BMark KinaseMarkkProstate-Derived Sterile 20-Like Kinase 2Psk-2Psk2Prostate-Derived Ste20-Like Kinase 2Thousand And One Amino Acid Protein Kinase 1Taok1Htaok1 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Tao1 antibodyAnti-Kinase From Chicken Homolog B antibodyAnti-Hkfc-B antibodyAnti-Mark Kinase antibodyAnti-Markk antibodyAnti-Prostate-Derived Sterile 20-Like Kinase 2 antibodyAnti-Psk-2 antibodyAnti-Psk2 antibodyAnti-Prostate-Derived Ste20-Like Kinase 2 antibodyAnti-Thousand And One Amino Acid Protein Kinase 1 antibodyAnti-Taok1 antibodyAnti-Htaok1 antibodyAnti-TAOK1 antibodyAnti-KIAA1361 antibodyAnti-MAP3K16 antibodyAnti-MARKK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
