| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TAF3 |
| Gene ID: | 83860 |
| Uniprot ID: | TAF3_HUMAN |
| Immunogen Region: | 50-150 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TAF3 (NP_114129.1). |
| Immunogen Sequence: | HRYSELYGRTDPILDDVGEA FQLMGVSLHELEDYIHNIEP VTFPHQIPSFPVSKNNVLQF PQPGSKDAEERKEYIPDYLP PIVSSQEEEEEEQVPTDGGT S |
| Function | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF3 forms the TFIID-A module together with TAF5 and TBP. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The TAF3-TBPL2 complex replaces TFIID at specific promoters at an early stage in the differentiation process. |
| Protein Name | Transcription Initiation Factor Tfiid Subunit 3140 Kda Tata Box-Binding Protein-Associated FactorTbp-Associated Factor 3Transcription Initiation Factor Tfiid 140 Kda SubunitTaf(Ii140Taf140Tafii-140Tafii140 |
| Database Links | Reactome: R-HSA-167161Reactome: R-HSA-167162Reactome: R-HSA-167172Reactome: R-HSA-674695Reactome: R-HSA-6804756Reactome: R-HSA-73776Reactome: R-HSA-73779Reactome: R-HSA-75953Reactome: R-HSA-76042 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Initiation Factor Tfiid Subunit 3 antibodyAnti-140 Kda Tata Box-Binding Protein-Associated Factor antibodyAnti-Tbp-Associated Factor 3 antibodyAnti-Transcription Initiation Factor Tfiid 140 Kda Subunit antibodyAnti-Taf(Ii140 antibodyAnti-Taf140 antibodyAnti-Tafii-140 antibodyAnti-Tafii140 antibodyAnti-TAF3 antibody |
Information sourced from Uniprot.org