| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TACC3 (20-140) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TACC3 |
| Gene ID: |
10460 |
| Uniprot ID: |
TACC3_HUMAN |
| Immunogen Region: |
20-140 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human TACC3 (NP_006333.1). |
| Immunogen Sequence: |
CDFLFSPPEVTGRSSVLRVS QKENVPPKNLAKAMKVTFQT PLRDPQTHRILSPSMASKLE APFTQDDTLGLENSHPVWTQ KENQQLIKEVDAKTTHGILQ KPVEADTDLLGDASPAFGSG S |
| Function | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. May be involved in the control of cell growth and differentiation. May contribute to cancer. |
| Protein Name | Transforming Acidic Coiled-Coil-Containing Protein 3Eric-1 |
| Database Links | Reactome: R-HSA-9013507Reactome: R-HSA-9604323 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleSpindle PoleIn Complex With Ckap5 Localized To Microtubule Plus-Ends In Mitosis And InterphaseIn Complex With Ckap5 And Clathrin Localized To Inter-Microtubule Bridges In Mitotic Spindles |
| Alternative Antibody Names | Anti-Transforming Acidic Coiled-Coil-Containing Protein 3 antibodyAnti-Eric-1 antibodyAnti-TACC3 antibodyAnti-ERIC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
