Immunofluorescence analysis of U2OS cells using TACC3 Rabbit polyclonal antibody (STJ11100575) at dilution of 1:100. Blue: DAPI for nuclear staining.

Anti-TACC3 antibody (20-140) (STJ11100575)

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STJ11100575
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Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TACC3
Gene ID: 10460
Uniprot ID: TACC3_HUMAN
Immunogen Region: 20-140
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human TACC3 (NP_006333.1).
Immunogen Sequence: CDFLFSPPEVTGRSSVLRVS QKENVPPKNLAKAMKVTFQT PLRDPQTHRILSPSMASKLE APFTQDDTLGLENSHPVWTQ KENQQLIKEVDAKTTHGILQ KPVEADTDLLGDASPAFGSG S
Function Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. May be involved in the control of cell growth and differentiation. May contribute to cancer.
Protein Name Transforming Acidic Coiled-Coil-Containing Protein 3
Eric-1
Database Links Reactome: R-HSA-9013507
Reactome: R-HSA-9604323
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Spindle
Spindle Pole
In Complex With Ckap5 Localized To Microtubule Plus-Ends In Mitosis And Interphase
In Complex With Ckap5 And Clathrin Localized To Inter-Microtubule Bridges In Mitotic Spindles
Alternative Antibody Names Anti-Transforming Acidic Coiled-Coil-Containing Protein 3 antibody
Anti-Eric-1 antibody
Anti-TACC3 antibody
Anti-ERIC1 antibody

Information sourced from Uniprot.org

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