| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | STX3 |
| Gene ID: | 6809 |
| Uniprot ID: | STX3_HUMAN |
| Immunogen Region: | 1-263 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-263 of human Syntaxin 3 (NP_004168.1). |
| Immunogen Sequence: | MKDRLEQLKAKQLTQDDDTD AVEIAIDNTAFMDEFFSEIE ETRLNIDKISEHVEEAKKLY SIILSAPIPEPKTKDDLEQL TTEIKKRANNVRNKLKSMEK HIEEDEVRSSADLRIRKSQH SVLSRKFVEVMTKYNEAQVD FRERSKGRIQRQLEITGKKT TDEELEEMLESGNPAIFTSG IIDSQISKQALSEIEGRHKD IVRLESSIKELHDMFMDIAM LVENQGEMLDNIELNVMHT |
| Tissue Specificity | Isoform A: Expressed in small intestine, kidney, pancreas, placenta as well as in retina. Weaker expression in lung, liver and heart. Not expressed in brain and skeletal muscle. Isoform B: Expressed only in the retina. Isoform 3: Ubiquitously expressed. |
| Function | Potentially involved in docking of synaptic vesicles at presynaptic active zones. Apical receptor involved in membrane fusion of apical vesicles. Isoform B: Essential for survival of retinal photoreceetors. Isoform 3: Functions as a regulator of gene expression. |
| Protein Name | Syntaxin-3 |
| Database Links | Reactome: R-HSA-449836 |
| Cellular Localisation | Isoform A: Apical Cell MembraneSingle-Pass Type Iv Membrane ProteinLocalized To The Inner And Outer Plexiform LayersThe Cell Body And The Inner Segments Of PhotoreceptorsIsoform 3: Nucleus |
| Alternative Antibody Names | Anti-Syntaxin-3 antibodyAnti-STX3 antibodyAnti-STX3A antibody |
Information sourced from Uniprot.org