| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SUGT1 |
| Gene ID: | 10910 |
| Uniprot ID: | SGT1_HUMAN |
| Immunogen Region: | 159-333 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 159-333 of human SUGT1 (NP_006695.1). |
| Immunogen Sequence: | NVQKNDVNVEFSEKELSALV KLPSGEDYNLKLELLHPIIP EQSTFKVLSTKIEIKLKKPE AVRWEKLEGQGDVPTPKQFV ADVKNLYPSSSPYTRNWDKL VGEIKEEEKNEKLEGDAALN RLFQQIYSDGSDEVKRAMNK SFMESGGTVLSTNWSDVGKR KVEINPPDDMEWKKY |
| Post Translational Modifications | Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex. |
| Function | May play a role in ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Protein Sgt1 HomologProtein 40-6-3Sgt1Suppressor Of G2 Allele Of Skp1 Homolog |
| Database Links | Reactome: R-HSA-844456Reactome: R-HSA-9660826 |
| Cellular Localisation | CytoplasmNucleusTranslocates To The Nucleus Upon Heat ShockRequiring S100a6 |
| Alternative Antibody Names | Anti-Protein Sgt1 Homolog antibodyAnti-Protein 40-6-3 antibodyAnti-Sgt1 antibodyAnti-Suppressor Of G2 Allele Of Skp1 Homolog antibodyAnti-SUGT1 antibody |
Information sourced from Uniprot.org