| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Substance P (1-100) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IF/ICC 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TAC1 |
| Gene ID: |
6863 |
| Uniprot ID: |
TKN1_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Substance P (NP_003173.1). |
| Immunogen Sequence: |
MKILVALAVFFLVSTQLFAE EIGANDDLNYWSDWYDSDQI KEELPEPFEHLLQRIARRPK PQQFFGLMGKRDADSSIEKQ VALLKALYGHGQISHKRHKT |
| Post Translational Modifications | Substance P: The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME). |
| Function | Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. |
| Protein Name | Protachykinin-1Ppt Cleaved Into - Substance P - Neurokinin ANkaNeuromedin LSubstance K - Neuropeptide KNpk - Neuropeptide Gamma - C-Terminal-Flanking Peptide |
| Database Links | Reactome: R-HSA-380095Reactome: R-HSA-416476 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Protachykinin-1 antibodyAnti-Ppt Cleaved Into - Substance P - Neurokinin A antibodyAnti-Nka antibodyAnti-Neuromedin L antibodyAnti-Substance K - Neuropeptide K antibodyAnti-Npk - Neuropeptide Gamma - C-Terminal-Flanking Peptide antibodyAnti-TAC1 antibodyAnti-NKA antibodyAnti-NKNA antibodyAnti-TAC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
