Immunofluorescence analysis of SH-SY5Y cells using [KO Validated] Substance P Rabbit polyclonal antibody (STJ11103444) at dilution of 1:300 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.

Anti-Substance P antibody (1-100) (STJ11103444)

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STJ11103444
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Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:100-1:500
IF/ICC:1:100-1:500
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TAC1
Gene ID: 6863
Uniprot ID: TKN1_HUMAN
Immunogen Region: 1-100
Specificity: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Substance P (NP_003173.1).
Immunogen Sequence: MKILVALAVFFLVSTQLFAE EIGANDDLNYWSDWYDSDQI KEELPEPFEHLLQRIARRPK PQQFFGLMGKRDADSSIEKQ VALLKALYGHGQISHKRHKT
Post Translational Modifications Substance P: The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME).
Function Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Protein Name Protachykinin-1
Ppt Cleaved Into - Substance P - Neurokinin A
Nka
Neuromedin L
Substance K - Neuropeptide K
Npk - Neuropeptide Gamma - C-Terminal-Flanking Peptide
Database Links Reactome: R-HSA-380095
Reactome: R-HSA-416476
Cellular Localisation Secreted
Alternative Antibody Names Anti-Protachykinin-1 antibody
Anti-Ppt Cleaved Into - Substance P - Neurokinin A antibody
Anti-Nka antibody
Anti-Neuromedin L antibody
Anti-Substance K - Neuropeptide K antibody
Anti-Npk - Neuropeptide Gamma - C-Terminal-Flanking Peptide antibody
Anti-TAC1 antibody
Anti-NKA antibody
Anti-NKNA antibody
Anti-TAC2 antibody

Information sourced from Uniprot.org

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