| Post Translational Modifications | Phosphorylated, leading to STXBP5L increased turnover and subsequent de-repression of insulin secretion. Phosphorylated on serine residues in response to glucose or phorbol esters. Ubiquitinated by the E3 ligase SYVN1, leading to STXBP5L proteasomal degradation. |
| Function | Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation. Promotes as well axonal outgrowth. |
| Protein Name | Syntaxin-Binding Protein 5-LikeLethal(2 Giant Larvae Protein Homolog 4Tomosyn-2 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinMembraneCytoplasmicAnd Associated With Vesicular Membranes And The Plasma Membrane |
| Alternative Antibody Names | Anti-Syntaxin-Binding Protein 5-Like antibodyAnti-Lethal(2 Giant Larvae Protein Homolog 4 antibodyAnti-Tomosyn-2 antibodyAnti-STXBP5L antibodyAnti-KIAA1006 antibodyAnti-LLGL4 antibody |
Information sourced from Uniprot.org
