| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | STRADB |
| Gene ID: | 55437 |
| Uniprot ID: | STRAB_HUMAN |
| Immunogen Region: | 209-418 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 209-418 of human STRADB (NP_061041.2). |
| Immunogen Sequence: | LVKHGQRHRAVYDFPQFSTS VQPWLSPELLRQDLHGYNVK SDIYSVGITACELASGQVPF QDMHRTQMLLQKLKGPPYSP LDISIFPQSESRMKNSQSGV DSGIGESVLVSSGTHTVNSD RLHTPSSKTFSPAFFSLVQL CLQQDPEKRPSASSLLSHVF FKQMKEESQDSILSLLPPAY NKPSISLPPVLPWTEPECDF PDEKDSYWEF |
| Tissue Specificity | Highly expressed in heart, skeletal muscle, testis, liver and colon. |
| Function | Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. |
| Protein Name | Ste20-Related Kinase Adapter Protein BetaStrad BetaAmyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 ProteinCals-21Ilp-Interacting ProteinPseudokinase Als2cr2 |
| Database Links | Reactome: R-HSA-380972 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Ste20-Related Kinase Adapter Protein Beta antibodyAnti-Strad Beta antibodyAnti-Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein antibodyAnti-Cals-21 antibodyAnti-Ilp-Interacting Protein antibodyAnti-Pseudokinase Als2cr2 antibodyAnti-STRADB antibodyAnti-ALS2CR2 antibodyAnti-ILPIP antibodyAnti-PRO1038 antibody |
Information sourced from Uniprot.org