| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-STK10 (320-510) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
STK10 |
| Gene ID: |
6793 |
| Uniprot ID: |
STK10_HUMAN |
| Immunogen Region: |
320-510 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 320-510 of human STK10 (NP_005981.3). |
| Immunogen Sequence: |
DGRDEGEEEDAVDAASTLEN HTQNSSEVSPPSLNADKPLE ESPSTPLAPSQSQDSVNEPC SQPSGDRSLQTTSPPVVAPG NENGLAVPVPLRKSRPVSMD ARIQVAQEKQVAEQGGDLSP AANRSQKASQSRPNSSALET LGGEKLANGSLEPPAQAAPG PSKRDSDCSSLCTSESMDYG TNLSTDLSLNK |
| Tissue Specificity | Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung. |
| Post Translational Modifications | Autophosphorylates following homodimerization, leading to activation of the protein. |
| Function | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro.however such data require additional evidences in vivo. |
| Protein Name | Serine/Threonine-Protein Kinase 10Lymphocyte-Oriented Kinase |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
| Cellular Localisation | Cell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase 10 antibodyAnti-Lymphocyte-Oriented Kinase antibodyAnti-STK10 antibodyAnti-LOK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of PC-12 cells using [KO Validated] KEAP1 Rabbit polyclonal antibody (STJ11104499) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/177143/368561/STJ11104499_1__57159.1713134043.jpg?c=1 "Immunofluorescence analysis of PC-12 cells using [KO Validated] KEAP1 Rabbit polyclonal antibody (STJ11104499) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")
