| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-STIL (1218-1287) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
STIL |
| Gene ID: |
6491 |
| Uniprot ID: |
STIL_HUMAN |
| Immunogen Region: |
1218-1287 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1218-1287 of human STIL (NP_003026.2). |
| Immunogen Sequence: |
LVKNLKPSPAVNLRTGKAEF TQHPEKENEGDITIFPESLQ PSETLKQMNSMNSVGTFLDV KRLRQLPKLF |
| Tissue Specificity | Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer. |
| Post Translational Modifications | Ubiquitinated. Phosphorylated following the activation of the mitotic checkpoint. |
| Function | Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation.its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly. |
| Protein Name | Scl-Interrupting Locus ProteinTal-1-Interrupting Locus Protein |
| Cellular Localisation | CytoplasmCytosolCytoskeletonMicrotubule Organizing CenterCentrosomeCentriole |
| Alternative Antibody Names | Anti-Scl-Interrupting Locus Protein antibodyAnti-Tal-1-Interrupting Locus Protein antibodyAnti-STIL antibodyAnti-SIL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
